[Fix] Application Load error S:0000065432 – Fallout 4

“Application Load error S:0000065432” error is often triggered by an antivirus program on your computer blocking Fallout 4.

Fix 1: Run Fallout 4 as an Administrator and Verify files

The steps below will help you fix this problem:

Before anything, remove any custom mods or textures you’ve applied to the game.

  • Right-click on Steam client and go to Properties.
  • Select the Compatibility tab from the drop-down menu.
  • Check the box that says “Run this software as an administrator
  • After that, click Apply, then OK.
  • Start Steam.
  • Right-click on Fallout 4 in the Steam Library and pick Properties.
  • Go to the Files tab and then to the Local Files tab.
  • Click on the Verify integrity of game files button.

Lastly, don’t forget that Fallout 4 and Steam must be excluded from any antivirus software (Both Windows Defender or Third-party).

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